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Psoriasis and comorbid diseases part i epidemiology. LIVIVO - Search results -

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    psoriasis and comorbid diseases part i epidemiology

    BMC musculoskeletal disorders Volume 16, Page s Abstract: Background: The aim of the present study is to evaluate serum osteoprotegerin OPG and soluble receptor activator of nuclear factor κB ligand sRANKL levels in a randomly selected male cohort over 50 years of age and its association with cystatin C, a Abstract Background: The aim of the present study is to evaluate serum osteoprotegerin OPG and soluble receptor activator of nuclear factor κB ligand sRANKL levels in a randomly selected male cohort over 50 years of age and its association with cystatin C, a cysteine proteinase inhibitor that decreases formation of osteoclasts by interfering at a late stage of pre-osteoclast differentiation, apart from being a marker of renal function independent of gender, muscle mass and age; in addition to known predictors such as age, sex hormones, vitamin D, bone mineral density BMD and biochemical markers of bone turnover.

    Methods: We determined serum OPG and sRANKL levels and examined its relationship with cystatin C, age, osteocalcin, C-terminal telopeptides of type-I collagen, procollagen type 1 amino-terminal propeptide, hydroxyvitamin D, parathyroid hormone, total 17β-estradiol E2total testosterone and L1-L4 LS and femur neck FN BMD data available from age, range: years randomly selected ambulatory men belonging to the HunMen cohort. Conclusions: The results of this study demonstrated that in addition to age which was the stronger predictorother modifiable factors such as cystatin C, FTI and E2 were also significant predictors of OPG, and that the association between cystatin C and OPG was more evident with increased age older age group.

    psoriasis and comorbid diseases part i epidemiology