University College, London Rövid összefoglaló The aim of this study is to investigate the mechanisms behind the immune dysfunction that occurs in atopic eczema or atopic dermatitis.
It results from a complex interaction of genetic and environmental factors, and is characterised by dysregulation of the cutaneous immune system. Specifically, in the skin of eczema patients there is a persistence of T lymphocytes a crucial cell involved in regulating the immune systemand an overproduction of certain cytokines signalling molecules that are essential in producing inflammatory responses.
The study intends to investigate the causes of atopic eczema by examining atopic eczema number, characteristics and function of T lymphocytes in the skin and the blood of eczema patients, as well as the types of cytokine they produce.
To achieve this the investigators aim atopic eczema take skin biopsies, tissue fluid from induced skin suction blisters and blood samples from atopic eczema eczema patients and healthy controls for analysis. Additionally, in these groups a cutaneous immune response will be initiated by injecting tuberculin protein purified derivative the Mantoux test into the skin, to further investigate how the behaviour of T lymphocytes varies between eczema patients and healthy controls.
This research is important in view of the high prevalence of atopic eczema in the population. An improved understanding of its causes will hopefully lead to more effective treatments for this condition in future.